Methamphetamine use in Europe is much lower than in other regions of the world, and is generally concentrated in Czechia and Slovakia. Three EU Member States have recent estimates of high-risk methamphetamine use, ranging from 0.55 per 1 000 population (330 high-risk users) in Cyprus to 5.04 per 1 000 (34 600 high-risk users) in Czechia (EMCDDA, 2021a). According to estimates by the Czech authorities, 6.5 tonnes of methamphetamine is produced annually in Czechia, with this quantity, excluding amounts seized by law enforcement, believed to be consumed by users in and around Czechia.